Combination of multimodality therapy with regional hyperthermia is a rewarding method to improve local tumor control rate and long term survival in children with high-risk tumors with dismal prognosis. Hyperthermia helps chemo refractory tumors to overcome their resistance to earlier applied chemotherapy. High quality hyperthermia is associated with treatment outcome and hence technological innovation will contribute to further enhance treatment outcome. Multiple channel heat applicators and non-invasive MR temperature monitoring for childhood cancer can produce precise target volumes with substantial sparing of normal tissue.