Strategies to optimize tacrolimus treatment and improve long-term clinical outcomes in solid organ transplantation

Although tacrolimus has been in widespread use since the 1990s, there are still a number of unanswered questions related to its clinical use. For example, the optimal starting dose of tacrolimus and the optimal target concentration in both the early and late phase after transplantation, are unknown.
At present, the main challenge to transplant physicians is to improve the long-term outcomes of solid organ transplantation while maintaining the good short-term outcomes that have already been achieved. The aim of this dissertation was to try and answer some of these questions and to find strategies to optimize tacrolimus treatment with the ultimate aim to improve the long-term outcomes of solid organ transplantation.