The research described in this thesis addressed several aspects of the management of congenital diaphragmatic hernia (CDH) after the introduction of a standardized neonatal treatment protocol. Most studies involved multicentre collaborative efforts of members of the CDH EURO Consortium. This is a collaboration between tertiary European centres with an expertise in CDH.
Part II focusses on clinical parameters and biomarkers with a potential predictive role. In part III different aspects of the treatment of CDH patients are described, including findings of a randomized clinical trial on initial ventilation strategy. Part IV studies the neurodevelopmental outcome in high-risk CDH infants at the ages of one and two years. In Part V the influences of patient characteristics and center specific differences are evaluated with respect to outcome.

The studies described in this thesis were supported by the ‘Sophia Stichting Wetenschappelijk Onderzoek’ (project 549), Rotterdam, The Netherlands.
D. Tibboel (Dick) , R.M.H. Wijnen (René) , H. IJsselstijn (Hanneke)
Erasmus University Rotterdam
Erasmus MC: University Medical Center Rotterdam

Snoek, K. (2016, June 15). A Dive into the Wondrous World of Congenital Diaphragmatic Hernia. Retrieved from