We analysed the association of independent variables with non-verbal cognition at 6 years in children with complete data (3441 from a cohort of 9901), of whom 415 were anaesthetised before the age of 5 years. Using multivariable regression, cognition was reduced by a mean (95% CI) score for children: anaesthetised before the age of 5 years, 2.1 (0.7-3.5), p = 0.004; born prematurely, 9.8 (4.1-15.4), p = 0.001; whose mothers smoked while pregnant, 2.3 (0.8-3.8), p = 0.004; whose mothers had lower IQ scores, 0.3 (0.2-0.3) for each unit reduction in maternal IQ, p < 0.0001. The association of child IQ with exposure to anaesthetic drugs was sensitive to missing data.

Additional Metadata
Keywords Anaesthetic drugs, Children, Intelligence quotient scores, Neurodevelopment, Neurotoxicity
Persistent URL dx.doi.org/10.1111/anae.13687, hdl.handle.net/1765/93483
Journal Anaesthesia
de Heer, I.J., Tiemeier, H.W, Hoeks, S.E, & Weber, F. (2017). Intelligence quotient scores at the age of 6 years in children anaesthetised before the age of 5 years. Anaesthesia, 72(1), 57–62. doi:10.1111/anae.13687