Naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization
Ferret coronaviruses (FRCoVs) exist as an enteric and a systemic pathotype, of which the latter is highly lethal to ferrets. To our knowledge, this study provides the first full genome sequence of a FRCoV, tentatively called FRCoV-NL-2010, which was detected in 2010 in ferrets in The Netherlands. Phylogenetic analysis showed that FRCoV-NL-2010 is most closely related to mink CoV, forming a separate clade of mustelid alphacoronavirus that split off early from other alphacoronaviruses. Based on sequence homology of the complete genome, we propose that these mustelid coronaviruses may be assigned to a new species. Comparison of FRCoV-NL- 2010 with the partially sequenced ferret systemic coronavirus MSU-1 and ferret enteric coronavirus MSU-2 revealed that recombination in the spike, 3c and envelope genes occurred between different FRCoVs.
|Keywords||Alphacoronavirus, Complete genome, Ferret coronavirus, Recombination|
|Persistent URL||dx.doi.org/10.1099/jgv.0.000520, hdl.handle.net/1765/93487|
|Journal||Journal of General Virology|
Lamers, M.M, Smits, S.L, Hundie, G.B, Provacia, L.B.V, Koopmans, M. (Marion), Osterhaus, A.D.M.E, … Raj, V.S. (2016). Naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization. Journal of General Virology, 97(9), 2180–2186. doi:10.1099/jgv.0.000520