Acquired demyelinating syndromes (ADS) cover a broad spectrum of central nervous system (CNS) inflammatory demyelinating syndromes, of which multiple sclerosis (MS) is the most common subtype. This thesis focuses on two relatively rare clinical subtypes of ADS: neuromyelitis optica spectrum disorders (NMOSD) and childhood-onset MS. Awareness and recognition of uncommon ADS subtypes are of importance for clinicians, since those require a distinct diagnostic and therapeutic approach. Here we aimed to reveal the spectrum of ADS by describing the clinical features of NMOSD and childhood-onset ADS, in order to improve the diagnostic process. In addition, we searched for prognostic and diagnostic biomarkers in ADS.

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R.Q. Hintzen (Rogier) , R.F. Neuteboom (Rinze)
Erasmus University Rotterdam
Printing of this thesis was financially supported by the Dutch MS Research Foundation, Erasmus University Medical Center Rotterdam, and Sanofi Genzyme.

The research described in this thesis is supported by the Dutch MS Research Foundation. In addition the studies described in chapter 5 and 7 were funded by direct donations to MS research at the Hospital for Sick Children (Toronto, Canada) and the Canadian MS Scientific Research Foundation. Besides, the study reported in chapter 9 was supported by a program grant provided by the EC 7th framework programme of the Marie Curie Initial Training Network, The United Europeans for the Development of Pharmacogenomics in Multiple Sclerosis, the Dutch Organization for Scientific Research (ZON—MW) and the Brain Foundation Netherlands.

Department of Neurology

van Pelt - Gravesteijn, D. (2016, October 12). Acquired Demyelinating Syndromes: Focus on Neuromyelitis Optica and childhood-onset Multiple Sclerosis. Retrieved from