Migration of Fibroblastoid Stromal Cells In Murine Blood

This paper describes the kinetics of fibroblastic colony forming units (CFU‐f) in murine blood after phenylhydrazine‐induced haemolytic anaemia and their subsequent migration into haemopoietic organs. Murine blood contained 5.3 φ 0.8 CFU‐f per 106 nucleated cells. Absence of particle ingestion and factor VIII‐related antigen in addition to the enzyme pattern in CFU‐f‐derived cells confirmed that these cells did not have a macrophage‐like or endothelial nature. Phenylhydrazine treatment of mice resulted in a 3‐fold increase in blood CFU‐f numbers which was accompanied by increases in blood cellularity and granulocyte‐macrophage progenitor numbers. When both partners of CBA/N and CBA/T6T6 mice in parabiosis had been treated with phenylhydrazine, spleens and femoral bone marrow of both mice were shown to contain partner‐derived CFU‐f. These data suggest that circulating CFU‐f represent a stromal cell population which can migrate into haemopoietic organs. Copyright

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