ABSTRACT. Increased fecal bile acid loss in cystic fibrosis (CF) may result from ileal dysfunction. A method to quantitate in vitro Na+‐dependent taurocholate uptake into brush border membrane vesicles prepared from frozen ileum and ileal biopsy specimen is described. This transport across the ileal brush border membrane can be measured selectively, in contrast to in vivo measurements which represent a complex overall process. Preliminary results obtained with ileal specimen of 2 CF patients, suggest that in vitro bile acid uptake is low but not abnormal. Copyright

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doi.org/10.1111/j.1651-2227.1985.tb14931.x, hdl.handle.net/1765/93634
Acta Paediatrica: promoting child health
Department of Internal Medicine

de Rooij, F., van den Berg, W., Sinaasappel, M., Bosman-Jacobs, E.P., & Touw-Blommesteijn, A. C. (1985). Bile Acid Malabsorption in Cystic Fibrosis; Membrane Vesicles, a Tool for Revealing the Role of the Ileal Brush Border Membrane. Acta Paediatrica: promoting child health, 74, 28–30. doi:10.1111/j.1651-2227.1985.tb14931.x