Neonatal critical illness and development: white matter and hippocampus alterations in school-age neonatal ECMO survivors
Aim: Examine the neurobiology of long-term neuropsychological deficits following neonatal extracorporeal membrane oxygenation (ECMO).
Method: This cross-sectional study assessed white matter integrity and hippocampal volume of ECMO survivors (8-15yrs) and healthy controls (8-17yrs) using Diffusion Tensor Imaging and structural MRI, respectively. Neuropsychological outcome was evaluated in patients. Included clinical predictors of white matter integrity: age start ECMO, ECMO duration, highest oxygenation index before ECMO, highest mean airway pressure and mechanical ventilation duration.
Results: Patients (n=23) had lower global fractional anisotropy than controls (n=54)(patients=.368; controls=.381; p=.02), but similar global mean diffusivity (p=.41). Patients had lower fractional anisotropy in the left cingulum bundle (patients=.345; controls=.399; p<.001) and higher mean diffusivity in a region of the left parahippocampal cingulum (patients=.916; controls=.871; p<.001). Higher global mean diffusivity predicted worse verbal memory in patients (n=17)(β=-.74, p=.01). Patients (n=23) had smaller bilateral hippocampal volume than controls (n=43)(left: p< .001; right: p< .001). In patients, this was related to worse verbal memory (left: β=.65, p=.02; right: β=.71, p=.01).
Interpretation: Neonatal ECMO survivors are at risk for long-term brain alterations, which may partly explain long-term neuropsychological impairments. Neuroimaging may contribute to better risk stratification of long-term impairments.
|Keywords||extracorporeal membrane oxygenation (ECMO)|
|Persistent URL||dx.doi.org/10.1111/dmcn.13309, hdl.handle.net/1765/93651|
|Journal||Developmental Medicine and Child Neurology|
Schiller, R.M, van den Bosch, G.E, Muetzel, R.L, Smits, M, Dudink, J, Tibboel, D, … White, T.J.H. (2017). Neonatal critical illness and development: white matter and hippocampus alterations in school-age neonatal ECMO survivors. Developmental Medicine and Child Neurology, 59(3), 304–310. doi:10.1111/dmcn.13309