Von Willebrand Factor plays an important role in primary hemostasis by platelet adhesion and aggregation. High molecular weight VWF multimers are the most procoagulant forms and are cleaved by ADAMTS13 (A Disintegrin And Metalloprotease with ThromboSpondin motif repeats 13) into smaller, less coagulant, forms.

Recent studies have shown an association between both high VWF levels, low ADAMTS13 levels and arterial thrombosis, including ischemic stroke and acute coronary syndrome. In this thesis several studies on VWF, ADAMTS13 and arterial thrombosis have been presented.

We conclude that the extent of atherosclerosis is strongly associated with VWF levels. Furthermore, VWF might be a marker of an unfavorable outcome in coronary heart disease and ischemic stroke patients. Plaque characteristics, such as high risk lesions, do not seem to be associated with VWF levels. Lastly, low ADAMTS13 is strongly associated with an increased risk of arterial thrombosis, including ischemic stroke and coronary heart disease. Overall, the studies in this thesis provide a better understanding of the role of VWF and ADAMTS13 in arterial thrombosis.

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F.W.G. Leebeek (Frank) , M.P.M. de Maat (Moniek) , M.A. Ikram (Arfan)
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2007B159), Dutch Thrombosis Foundation (2010-3) and by Baxter (unrestricted grant). Printing of this thesis was financially supported by: Sanquin Blood Supply, Dutch Thrombosis Foundation, CSL Behring and Pfizer BV. Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged
Erasmus University Rotterdam
Department of Hematology

Sonneveld, M. (2016, October 25). Von Willebrand Factor and ADAMTS13 in Cardiovascular Disease. Retrieved from http://hdl.handle.net/1765/93807