Restore the Balance : Side effects of dexamethasone in children with acute lymphoblastic leukemia
Herstel de balans : bijwerkingen van dexamethason in kinderen met acute lymfatische leukemie
The aim of this study was threefold:
· The primary aim was to reduce dexamethasone-induced cerebral side effects on mood, behavior, sleep, and cognition by an intervention with physiological doses of cortisol.
· The secondary aim was to study whether dexamethasone-induced metabolic toxicity (i.e. hyperglycemia, insulin resistance, visceral fat gain, hypertension and hypercholesterolemia) occurred less frequently during intervention treatment compared to placebo.
· The third aim was to study the positive predictive value of a novel in vivo diagnostic test (salivary very low dose dexamethasone suppression test) on dexamethasone side effects.
|R. Pieters (Rob) , M.M. van den Heuvel-Eibrink (Marry) , E.L.T. van den Akker (Erica)|
|Erasmus University Rotterdam|
|The work described in this thesis was funded by Stichting Kinderen Kankervrij (KiKa) (Project 99). Printing of this thesis was financially supported by Nutricia Early Life Nutrition and Pfizer.|
|Organisation||Department of Pediatrics|
Warris, L.T. (2016, November 9). Restore the Balance : Side effects of dexamethasone in children with acute lymphoblastic leukemia. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/93913