The aim of this study was threefold:
· The primary aim was to reduce dexamethasone-induced cerebral side effects on mood, behavior, sleep, and cognition by an intervention with physiological doses of cortisol.
· The secondary aim was to study whether dexamethasone-induced metabolic toxicity (i.e. hyperglycemia, insulin resistance, visceral fat gain, hypertension and hypercholesterolemia) occurred less frequently during intervention treatment compared to placebo.
· The third aim was to study the positive predictive value of a novel in vivo diagnostic test (salivary very low dose dexamethasone suppression test) on dexamethasone side effects.

R. Pieters (Rob) , M.M. van den Heuvel-Eibrink (Marry) , E.L.T. van den Akker (Erica)
Erasmus University Rotterdam
The work described in this thesis was funded by Stichting Kinderen Kankervrij (KiKa) (Project 99). Printing of this thesis was financially supported by Nutricia Early Life Nutrition and Pfizer.
Department of Pediatrics

Warris, L. (2016, November 9). Restore the Balance : Side effects of dexamethasone in children with acute lymphoblastic leukemia. Retrieved from