ABSTRACT: Microcirculatory abnormalities have been shown to be frequent in patients with septic shock despite “normalization” of systemic hemodynamics. Several studies have explored the impact of vasodilator therapy (prostacyclin, inhaled nitric oxide, topic acetylcholine and nitroglycerin) on microcirculation and tissue perfusion, with contradictory findings.In this narrative review, we briefly present the pathophysiological aspects of microcirculatory dysfunction, and depict the evidence supporting the use of vasodilators and other therapeutic interventions (fluid administration, blood transfusion, vasopressors and dobutamine) aiming to improve the microcirculatory flow in septic shock patients.

Additional Metadata
Persistent URL dx.doi.org/10.1097/SHK.0000000000000777, hdl.handle.net/1765/94004
Journal Shock (Philadelphia)
Citation
Corrêa, T.D. (Thiago Domingos), Filho, R.R. (Roberto Rabello), Assunção, M.S.C. (Murillo Santucci Cesar), Silva, E. (Eliézer), & Lima, A.A.P. (2017). Vasodilators in Septic Shock Resuscitation: A Clinical Perspective. Shock (Philadelphia) (Vol. 47, pp. 269–275). doi:10.1097/SHK.0000000000000777