Wide clinical application of intravascular stenting devices is currently limited by occlusion or intraluminal narrowing caused by thrombosis and neointimal thickening in a considerable percentage of implantations. We studied the possibility of seeding one of the currently availiable stents, a stainless steel, self‐expandable wire‐mesh, with endothelial cells in vitro. Endothelial cells, derived from human umbilical cord veins, could be successfully attached to stent filaments. In vivo stent implantations in porcine femoral arteries showed complete covering of stent wires by endothelium after 1 week. We conclude that coating of stents with autologous endothelial cells prior to implantation might protect against early thrombosis during the period in which a neointima is formed. (J Interven Cardiol 1988:1:2) Copyright

doi.org/10.1111/j.1540-8183.1988.tb00395.x, hdl.handle.net/1765/94078
Journal of Interventional Cardiology: an international forum for global cardiovascular therapies
Department of Cardiology

van der Giessen, W., Serruys, P., W.J. Visser, Verdouw, P., van Schalkwijk, P., & Jongkind, J. F. (1988). Endothelialization of Intravascular Stents. Journal of Interventional Cardiology: an international forum for global cardiovascular therapies, 1(2), 109–120. doi:10.1111/j.1540-8183.1988.tb00395.x