Our aim was to study the prevalence of depression in a Dutch population with PBC and PSC. In addition, to investigate the effects of using an additional diagnostic structured psychiatric interview, after screening with the Beck Depression Inventory (BDI), a self-report severity scale instrument used in former studies. Patients with PBC and PSC (n = 92)completed the BDI. Patients with scores of 10 or higher (n = 39) were interviewed using a structured psychiatric interview. Patients with scores lower than 10 were at random (30/53, 57%) also interviewed using a structured psychiatric interview. Results: Of the 92 patients that were included 42% had depressive symptoms according to the BDI. However, of these patients only 3.7% had a depressive syndrome according to the DSM-IV criteria as assessed with the structured psychiatric interview. Conclusions: The prevalence of a depressive disorder in patients with PBC and PSC is not higher than in the general population. Fatigue in patients with PBC and PSC cannot be explained by depression.

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doi.org/10.1016/j.jhep.2007.01.036, hdl.handle.net/1765/9411
Journal of Hepatology
Erasmus MC: University Medical Center Rotterdam

van den Broek, W.W, van Os, E, Mulder, P.G.H, ter Borg, P.C.J, Bruijn, J.A, & van Buuren, H.R. (2007). Depression in patients with primary biliary cirrhosis and primary sclerosing cholangites. Journal of Hepatology, 46(6), 1099–1103. doi:10.1016/j.jhep.2007.01.036