As many drugs in paediatrics are used off-label, prescribers face a lack of evidence-based dosing guidelines. A Dutch framework was developed to provide dosing guidelines based on best available evidence from registration data, investigator-initiated research, professional guidelines, clinical experience and consensus. This has clarified the scientific grounds of drug use for children and encouraged uniformity in prescribing habits in the Netherlands. The developed framework and the current content of the Dutch Paediatric Formulary could be used as basis for similar initiatives worldwide, preferably in a concerted effort to ultimately provide children with effective and safe drug therapy.

Additional Metadata
Persistent URL dx.doi.org/10.1136/archdischild-2016-311674, hdl.handle.net/1765/94251
Journal Archives of Disease in Childhood: an international peer-reviewed journal for health professionals and researchers covering conception to adolescence
Citation
van der Zanden, T.M. (Tjitske M.), de Wildt, S.N, Liem, Y. (Yves), Offringa, M, & de Hoog, M. (2017). Developing a paediatric drug formulary for the Netherlands. Archives of Disease in Childhood: an international peer-reviewed journal for health professionals and researchers covering conception to adolescence. doi:10.1136/archdischild-2016-311674