Next Generation Diagnostic Molecular Pathology

In this thesis studies are described on the application of a variety of molecular analyses in solving diag¬nostic difficulties that remained unsolved based on clinical and histopathological characteristics. The first part, clonality determinations, focuses on the use of unique DNA markers or somatic DNA aberrations to define tumor origin or the clonal relationships be¬tween multiple tumors from one patient. The second part, molecular diagnostics in the context of heredi¬tary testing, focuses on the interface of germline and somatic diagnostics by clinical genetics and pathol¬ogy, respectively. The central theme of this thesis is the application of molecular analyses in a routine di¬agnostic setting.

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