The general aim of this thesis is to study different aspects of an acute HCV infection in HIV positive MSM. The primary aim is to study the effectivity and safety of boceprevir in addition to pegIFN and RBV for the treatment of acute HCV infections within the Dutch Acute HCV in HIV study (DAHHS). Subsequently, the DAHH-Study provided an unique opportunity to study the epidemiologic, clinical, immunologic and virologic characteristics of acute HCV infections among HIV positive MSM in the Netherlands