Growth hormone (GH) treatment effectively induces catch-up growth and improves adult height in short children born small for gestational age (SGA). Besides this visual effect, GH treatment also has several other effects which occur inside the body.

This doctoral thesis presents the effects of GH treatment, with or without additional gonadotropin-releasing hormone analog (GnRHa) treatment, on metabolic and cardiovascular risk factors. The effects of GnRHa treatment, in addition to GH treatment, on pubertal development are described. Further, the long-term effects of discontinuation of GH treatment are assessed in young adults born SGA. Finally, a new genetic cause for persistent short stature after SGA birth is revealed.

The results presented in this thesis illustrate that there is more to GH treatment than meets the eye.

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A.C.S. Hokken-Koelega (Anita)
Erasmus University Rotterdam
Department of Pediatrics

van der Steen, M. (2016, December 9). Growth Hormone Treatment in SGA : More than meets the eye. Retrieved from