Pharmacological and Interventional Approaches for Optimizing Taxane Treatment

The goal of this thesis was to improve current abilities in the management of taxane therapy using interventional and pharmacological approaches. Thereby aiming for providing patients with an optimally effective therapy, while reducing toxicity.
This thesis sheds new light on factors influencing the pharmacokinetics and pharmacodynamics of the taxanes paclitaxel, docetaxel and cabazitaxel, further optimizing taxane therapy.