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Queirós, A.C. (Ana C.), R. Beekman (Renée), Vilarrasa-Blasi, R. (Roser), Duran-Ferrer, M. (Martí), Clot, G. (Guillem), Merkel, A. (Angelika), Raineri, E. (Emanuele), Russiñol, N. (Nuria), Castellano, G. (Giancarlo), S. Bea (Silvia), et al. Navarro, A. (Alba), Kulis, M. (Marta), Verdaguer-Dot, N. (Núria), P. Jares (Pedro), A. Enjuanes (Anna), M.J. Calasanz (Maria), Bergmann, A. (Anke), Vater, I. (Inga), Salaverría, I. (Itziar), H.J.G. van de Werken (Harmen), W.H. Wilson (Wyndham), Datta, A. (Avik), P. Flicek (Paul), Royo, R. (Romina), J.H.A. Martens (Joost), Giné, E. (Eva), Lopez-Guillermo, A. (Armando), H. Stunnenberg (Henk), W. Klapper (Wolfram), C. Pott (Christiane), Heath, S. (Simon), I. Gut (Ivo), R. Siebert (Reiner), G. Campo (Gianluca) and J.I. Martin-Subero (J.)

2016-11-14

Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

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Cancer Cell , Volume 30 - Issue 5 p. 806- 821

We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We identified two MCL subgroups, respectively carrying epigenetic imprints of germinal-center-inexperienced and germinal-center-experienced B cells, and we found that DNA methylation profiles during lymphomagenesis are largely influenced by the methylation dynamics in normal B cells. An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11. Finally, we observed that the magnitude of DNA methylation changes per case is highly variable and serves as an independent prognostic factor for MCL outcome.

Additional Metadata
Keywords ChIP-seq, chromatin, DNA looping, DNA methylation, enhancer, epigenomics, lymphoma, mantle cell lymphoma, SOX11, whole-genome bisulfite sequencing
Persistent URL doi.org/10.1016/j.ccell.2016.09.014, hdl.handle.net/1765/95010
Journal Cancer Cell
Organisation Biophysical Genomics, Department Cell Biology & Genetics
Citation
Queirós, A.C. (Ana C.), Beekman, R., Vilarrasa-Blasi, R. (Roser), Duran-Ferrer, M. (Martí), Clot, G. (Guillem), Merkel, A. (Angelika), … Martin-Subero, J. (2016). Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage. Cancer Cell, 30(5), 806–821. doi:10.1016/j.ccell.2016.09.014
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