White matter lesions play a role in cognitive decline and dementia. One presumed pathway is through disconnection of functional networks. Little is known about location-specific effects of lesions on functional connectivity. This study examined location-specific effects within anatomically-defined white matter tracts in 1584 participants of the Rotterdam Study, aged 50–95. Tracts were delineated from diffusion magnetic resonance images using probabilistic tractography. Lesions were segmented on fluid-attenuated inversion recovery images. Functional connectivity was defined across each tract on resting-state functional magnetic resonance images by using gray matter parcellations corresponding to the tract ends and calculating the correlation of the mean functional activity between the gray matter regions. A significant relationship between both local and brain-wide lesion load and tract-specific functional connectivity was found in several tracts using linear regressions, also after Bonferroni correction. Indirect connectivity analyses revealed that tract-specific functional connectivity is affected by lesions in several tracts simultaneously. These results suggest that local white matter lesions can decrease tract-specific functional connectivity, both in direct and indirect connections.

Additional Metadata
Keywords Brain, Connectivity, Function, Lesions, Location-specific
Persistent URL dx.doi.org/10.1016/j.neurobiolaging.2016.12.004, hdl.handle.net/1765/95308
Journal Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/601055 - VPH Dementia Research Enabled by IT (VPH-DARE@IT)
Citation
Langen, C.D, Zonneveld, H.I. (Hazel I.), White, T.J.H, Huizinga, W, Cremers, L.G.M, de Groot, M, … Vernooij, M.W. (2017). White matter lesions relate to tract-specific reductions in functional connectivity. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 51, 97–103. doi:10.1016/j.neurobiolaging.2016.12.004