In this thesis, I have focused on obtaining more insight onto epigenetic signatures and events that appear during early embryo development or during differentiation of early embryo representatives.
By developing technical innovative approaches aimed at better detection of chromatin components and DNA, and at developing relevant models to study the molecular basis of X chromosome inactivation (XCI), I have aimed to contribute to insight in the regulation of PHC in primordial germ cells and in (imprinted) XCI in mouse and rat.

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J.H. Gribnau (Joost) , M. Eijpe (Maureen) , W.M. Baarends (Willy)
Erasmus University Rotterdam
Department of Developmental Biology

Magaraki, A. (2017, January 17). Epigenetic regulation in rodent primordial germ cells and preimplantation embryos. Retrieved from