This thesis describes the results of the first preventive randomized controlled trial worldwide in the field of knee osteoarthritis.
The preventive effectiveness of a tailor-made lifestyle intervention, consisting of diet and exercise, is described in detail. Short-term results are briefly discussed, but the focus is on long-term results and the achieved behavioural changes in lifestyle.
Additionally, the preventive effect of oral glucosamine sulfate on incident knee osteoarthritis is described. This thesis provides important insights in achieving sustainable lifestyle changes and novel insights in the prevention of knee osteoarthritis.

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S.M. Bierma-Zeinstra (Sita) , J. Runhaar (Jos)
Erasmus University Rotterdam
The work in this thesis is supported by ZonMw, The Netherlands Organisation of Health Research and Development, the Dutch Arthritis Foundation and by the D-Board project, which has received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration.
Department of General Practice

de Vos, B. (2017, February 7). Battling Obesity : efforts in preventing knee osteoarthritis. Retrieved from