STUDY OBJECTIVE: To assess the long-term prognostic value of dobutamine stress echocardiography (DSE) for cardiac events (cardiac death, myocardial infarction, and late revascularization) in patients with atrial fibrillation (AF). METHODS: Baseline ECGs were studied in patients undergoing DSE between 1989 and 1998. Sixty-nine patients had AF before DSE. Prognostic value of DSE in these patients was compared with a control group who had sinus rhythm (n = 1,664). The presence of stress-induced ischemia was noted for every patient. The mean follow-up period was 35 months (range, 6 to 84 months). Data are presented as hazards ratio (HR) with 95% confidence interval (CI). RESULTS: Heart rate at rest was higher in patients with AF (77 +/- 15 beats/min vs 73 +/- 14 beats/min; p = 0.04); however, double product at peak stress was not different between patients with AF and sinus rhythm (17,602 vs 17,169, respectively; p = 0.46). In patients with AF, target heart rate was achieved at a lower dobutamine dose (33 +/- 8 microg/kg/min vs 35 +/- 9 microg/kg/min; p = 0.01). Cardiac arrhythmias occurred more frequently (12% vs 5%; p = 0.001) in patients with AF during DSE. During a follow-up period of 7 years, cardiac death occurred in 5 patients, myocardial infarction in 2 patients, and late revascularization in 10 patients. Prognostic value of DSE for all late cardiac events was similar in patients with AF (HR, 3.0; 95% CI, 0.9 to 9.5) and sinus rhythm (HR, 3.4; 95% CI, 2.7 to 4.3; p = 0.85). CONCLUSION: The prognostic value of DSE for late cardiac events is maintained in patients with AF.

Additional Metadata
Keywords *Echocardiography, *Exercise Test, Aged, Atrial Fibrillation/mortality/*ultrasonography, Confidence Intervals, Dobutamine/*diagnostic use, Female, Follow-Up Studies, Humans, Male, Middle aged, Myocardial Infarction/mortality/ultrasonography, Myocardial Revascularization, Proportional Hazards Models, Risk Factors, Survival Rate
Persistent URL hdl.handle.net/1765/9569
Journal Chest: the cardiopulmonary and critical care journal
Citation
Poldermans, D, Bax, J.J, Elhendy, A, Sozzi, F, Thomson, I.R, Jordaens, L.J.L.M, & Boersma, H. (2001). Long-term prognostic value of dobutamine stress echocardiography in patients with atrial fibrillation. Chest: the cardiopulmonary and critical care journal. Retrieved from http://hdl.handle.net/1765/9569