Objective. To review evidence on the efficacy of HPV vaccines in the prevention of non-cancer lesions (anogenital warts [AGW], recurrent laryngeal papillomatosis and oral papillomatosis). Materials and methods. We conducted a systematic review of randomized trials. We performed random effect models and effects were reported as relative risks (RR) and their confidence intervals (95%CI) following both intention to treat (ITT) and per protocol (PP) analyses. Results. We included six studies (n=27 078). One study was rated as high risk of bias. One study could not be included in the meta-analysis because it provided combined results. We found that quadrivalent vaccine reduced the risk of AGW by 62% (RR: 0.38, 95%CI:0.32-0.45, I2:0%) in the ITT analysis and by 95% (RR: 0.05, 95%CI:0.01-0.25, I2:66%) in the PP analysis. Subgroup analyses of studies in women or with low-risk of bias provided similar results. Conclusion. HPV quadrivalent vaccine is efficacious in preventing AGW in men and women.

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doi.org/10.21149/7824, hdl.handle.net/1765/95700
Salud Publica de Mexico
Department of Epidemiology

Tejada, R.A. (Romina A.), Vargas, K. G., Benites-Zapata, V. A., Mezones-Holguín, E. (Edward), Bolaños-Díaz, R. (Rafael), & Hernández, A.V. (Adrián V.). (2017). Human papillomavirus vaccine efficacy in the prevention of anogenital warts: Systematic review and meta-analysis. Salud Publica de Mexico, 59(1), 84–94. doi:10.21149/7824