Purpose: To report on the beneficial results of an intense regimen of 0.05% cyclosporine eye drops, eight times a day in patients with therapy resistant vernal shield ulcers. Methods: Case cohort of four eyes of three male children with vernal keratoconjunctivitis complicated by shield ulcers, who were treated with frequent cyclosporine 0.05% eye drops and observed for up to 5 years. Results: Quick resolution of the shield ulcers and complete re-epithelialization within 14–25 days was observed after adding intensive treatment with cyclosporine 0.05% to regular anti-inflammatory, histamine blocking, and surgical therapy. In one patient, additional scraping of the bottom of the ulcer was needed. Conclusions: In patients with vernal shield ulcers, frequent installation of low-concentration cyclosporine eye drops seems to have a promising therapeutical value.

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doi.org/10.1007/s10792-016-0424-z, hdl.handle.net/1765/95715
International Ophthalmology
Department of Ophthalmology

Westland, T. (Tim), Patryn, E.K. (Eliza K.), Nieuwendaal, C., van der Meulen, I.J.E. (Ivanka J. E.), Mourits, M., & Lapid-Gortzak, R. (Ruth). (2017). Vernal shield ulcers treated with frequently installed topical cyclosporine 0.05% eyedrops. International Ophthalmology, 1–6. doi:10.1007/s10792-016-0424-z