Purpose: To study relationships between fatigue and objective and subjective cognitive functioning, mood and comorbidity in the long term after perimesencephalic subarachnoid haemorrhage (PM-SAH). Methods: Cross-sectional study. Objective cognitive functioning was measured with: Trail Making Test; Symbol Substitution; D2; Verbal and Semantic Fluency; Tower Test; Digit Span; 15-Words Test; Rey Complex Figure. Subjective cognitive functioning: Cognitive Failure Questionnaire. Fatigue: Fatigue Severity Scale. Mood: Hospital Anxiety and Depression Scale. Results: Forty-six patients, mean age 50.4 (SD = 9.4), mean time after PM-SAH 4.7 (SD = 1.6) years participated. Patients with fatigue (33%) had significantly lower scores than patients without fatigue on most objective cognitive functioning tests (p < 0.05). Fatigue score was significantly associated with subjective and objective cognitive functioning, mood and comorbidity. After adjustment for mood and comorbidity, fatigue remained associated with attention and executive functioning. Conclusions: This study supports our previous findings that a third of patients with PM-SAH experience fatigue and problems of cognitive functioning, also in the long term. Future research should investigate whether these patients would benefit from long-term follow-up and/or cognitive rehabilitation programmes.Implications for RehabilitationConsequences for patients with PM-SAH are underestimated.One in every three patients suffered from fatigue in the long term after onset of PM-SAH.Patients with PM-SAH should be screened for problems of cognitive functioning, fatigue and mood in outpatient clinic just as patients with aneurysmal SAH.

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Keywords Cognitive functioning, fatigue, haemorrhage, mood, perimesencephalic, subarachnoid
Persistent URL dx.doi.org/10.3109/09638288.2016.1172671, hdl.handle.net/1765/95902
Journal Disability and Rehabilitation
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Boerboom, W, Van Zandvoort, M.J.E, van Kooten, F, Khajeh, L, Visser-Meily, J.M.A. (Johanna M. A.), Ribbers, G.M, & Heijenbrok-Kal, M.H. (2017). Long-term fatigue after perimesencephalic subarachnoid haemorrhage in relation to cognitive functioning, mood and comorbidity. Disability and Rehabilitation, 39(9), 928–933. doi:10.3109/09638288.2016.1172671