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Bryushkova, L. (Lyubov), C.C. Zai (Clement), Chen, S. (Sheng), M. Pappa (Magda), Mileva, V. (Viara), H.W. Tiemeier (Henning), M.J. Bakermans-Kranenburg (Marian), J.L. Kennedy and Beitchman, J.H. (Joseph H.)

2016-08-30

FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression

Publication

Publication

Psychiatry Research , Volume 242 p. 277- 280

Genetic variation in stress response protein FKBP5 is associated with adult psychopathology, but little is known about its role in children's mental health. 5 polymorphisms were genotyped in 170 high aggression cases and 170 age- and sex-matched controls. The rs9470080 polymorphism was associated with physiological anxiety, while rs4713916 polymorphism interacted with maltreatment to influence externalizing traits. These results suggest that genetic variation in FKBP5 has a role in children's vulnerability to stress-related behaviours.

Additional Metadata
Keywords Child aggression, Gene-environment interaction, HPA axis
Persistent URL doi.org/10.1016/j.psychres.2015.09.052, hdl.handle.net/1765/96867
Journal Psychiatry Research
Organisation Generation R Study Group
Citation
Bryushkova, L., Zai, C., Chen, S., Pappa, M., Mileva, V., Tiemeier, H., … Beitchman, J. H. (2016). FKBP5 interacts with maltreatment in children with extreme, pervasive, and persistent aggression. Psychiatry Research, 242, 277–280. doi:10.1016/j.psychres.2015.09.052


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