C. Pattaro (Cristian),
A. Teumer (Alexander),
M. Gorski (Mathias),
A.Y. Chu (Audrey),
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Mijatovic, V. (Vladan),
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A. Tin (Adrienne),
R. Sorice,
Y. Li (Yong),
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D. Taliun (Daniel),
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A.D. Johnson (Andrew),
Ko, Y.-A. (Yi-An),
C. Fuchsberger (Christian),
B. Tayo (Bamidele),
M.A. Nalls (Michael),
M.F. Feitosa (Mary Furlan),
A. Isaacs (Aaron),
A. Dehghan (Abbas),
P. d' Adamo (Pio),
Adeyemo, A. (Adebowale),
A.K. Dieffenbach (Aida Karina),
A.B. Zonderman,
I.M. Nolte (Ilja M.),
P.J. van der Most (Peter),
A.F. Wright (Alan),
A.R. Shuldiner (Alan),
A.C. Morrison (Alanna),
Hofman, A. (Albert),
A.V. Smith (Albert V.),
A.W. Dreisbach (Albert),
A. Franke (Andre),
A.G. Uitterlinden (André),
A. Metspalu (Andres),
A. Tönjes (Anke),
A. Lupo (Antonio),
A. Robino (Antonietta),
A. Johansson (Åsa),
A. Demirkan (Ayşe),
B. Kollerits (Barbara),
Freedman, B.I. (Barry I.),
Ponte, B. (Belen),
B.A. Oostra (Ben),
Paulweber, B. (Bernhard),
B.K. Krämer (Bernhard),
B.D. Mitchell (Braxton),
B.M. Buckley (Brendan M.),
Peralta, C.A. (Carmen A.),
C. Hayward,
C. Helmer (Catherine),
C. Rotimi (Charles),
Shaffer, C.M. (Christian M.),
Müller, C. (Christian),
C. Sala (Cinzia),
C.M. van Duijn (Cornelia),
Saint-Pierre, A. (Aude),
Ackermann, D. (Daniel),
D. Shriner (Daniel),
D. Ruggiero,
D. Toniolo (Daniela),
Y. Lu (Yingchang),
D. Cusi (Daniele),
D. Czamara (Darina),
D. Ellinghaus (David),
D.S. Siscovick (David),
D. Ruderfer (Douglas),
C. Gieger (Christian),
H. Grallert (Harald),
E. Rochtchina (Elena),
E.J. Atkinson (Elizabeth),
E.G. Holliday (Elizabeth),
E.A. Boerwinkle (Eric),
Salvi, E. (Erika),
E.P. Bottinger (Erwin),
D. Murgia (Daniela),
F. Rivadeneira Ramirez (Fernando),
F.D.J. Ernst (Florian),
F. Kronenberg (Florian),
Hu, F.B. (Frank B.),
G. Navis (Gerjan),
Curhan, G.C. (Gary C.),
G.B. Ehret (Georg),
G. Homuth (Georg),
S. Coassin (Stefan),
G.-A. Thun (Gian-Andri),
G. Pistis (Giorgio),
G. Gambaro (Giovanni),
G. Malerba (Giovanni),
Montgomery, G.W. (Grant W.),
G. Eiriksdottir (Gudny),
G. Jacobs (Gunnar),
G. Li (Guo),
H.E. Wichmann (Heinz Erich),
H. Campbell (Harry),
H. Schmidt,
H. Wallaschofski (Henri),
H. Völzke (Henry),
H. Brenner (Hermann),
Kroemer, H.K. (Heyo K.),
H. Kramer (Holly),
Lin, H. (Honghuang),
I.M. Leach (Irene Mateo),
I. Ford,
I. Guessous (Idris),
I. Rudan (Igor),
I. Prokopenko (Inga),
I.B. Borecki (Ingrid),
I.M. Heid (Iris),
I. Kolcic (Ivana),
I. Persico (Ivana),
J.W. Jukema,
J.F. Wilson (James F.),
J.F. Felix (Janine),
Divers, J. (Jasmin),
J.-C. Lambert (Jean-Charles),
J.M. Stafford (Jeanette M.),
J.-M. Gaspoz (Jean-Michel),
J.A. Smith (Jennifer A),
J.D. Faul (Jessica D.),
J.J. Wang (Jie Jin),
Ding, J. (Jingzhong),
J.N. Hirschhorn (Joel N.),
J. Attia (John),
J.B. Whitfield (John B.),
J. Chalmers (John),
J. Viikari (Jorma),
J. Coresh (Josef),
Denny, J.C. (Joshua C.),
J. Karjalainen (Juha),
Fernandes, J.K. (Jyotika K.),
K. Endlich (Karlhans),
K. Butterbach (Katja),
K.L. Keene (Keith),
Lohman, K. (Kurt),
L. Portas (Laura),
L.J. Launer (Lenore),
L.-P. Lyytikäinen (Leo-Pekka),
L. Yengo (Loic),
L. Franke (Lude),
L. Ferrucci (Luigi),
L.M. Rose (Lynda),
L. Kedenko (Lyudmyla),
Rao, M. (Madhumathi),
M.V. Struchalin (Maksim),
M.E. Kleber (Marcus),
M. Cavalieri (Margherita),
M. Haun (Margot),
M. Cornelis (Marilyn),
Ciullo, M. (Marina),
M. Pirastu (Mario),
M. de Andrade (Mariza),
M. McEvoy (Mark),
M. Woodward (Mark),
M. Adam (Martin),
M. Cocca (Massimiliano),
M. Nauck (Matthias),
M. Imboden (Medea),
M. Waldenberger (Melanie),
Pruijm, M. (Menno),
M. Metzger (Marie),
M. Stumvoll (Michael),
M.K. Evans (Michele),
P. Sale (Patrizio),
M. Kähönen (Mika),
M. Boban (Mladen),
M. Bochud (Murielle),
Rheinberger, M. (Myriam),
N. Verweij (Niek),
N. Bouatia-Naji (Nabila),
Martin, N.G. (Nicholas G.),
N. Hastie (Nick),
N.M. Probst-Hensch (Nicole M.),
N. Soranzo (Nicole),
O. Devuyst (Olivier),
O. Raitakari (Olli),
R.F. Gottesman (Rebecca),
O.H. Franco (Oscar),
O. Polasek (Ozren),
P. Gasparini (Paolo),
Munroe, P.B. (Patricia B.),
P.M. Ridker (Paul),
P. Mitchell (Paul),
P. Muntner (Paul),
C. Meisinger (Christa),
,
G.R. Abecasis (Gonçalo),
L.S. Adair (Linda),
M.T. Alexander (Michael),
D. Altshuler (David),
,
D.E. Arking (Dan),
M. Arora (Manish),
Y.S. Aulchenko (Yurii),
S.J.L. Bakker (Stephan),
S. Bandinelli (Stefania),
I.E. Barroso (Inês),
J.S. Beckmann (Jacques),
J. Beilby (John),
R.N. Bergman (Richard N.),
S.M. Bergmann (Sven),
J.C. Bis (Joshua),
M. Boehnke (Michael),
L.L. Bonnycastle (Lori),
S.R. Bornstein (Stefan),
M.L. Bots (Michiel),
J.L. Bragg-Gresham (Jennifer L.),
S.-M. Brand,
E. Brand (Eddy),
P.S. Braund (Peter),
Brown, M.J. (Morris J.),
P.R. Burton (Paul),
Casas, J.P. (Juan P.),
Caulfield, M.J. (Mark J.),
A. Chakravarti (Aravinda),
J.C. Chambers (John C.),
G.R. Chandak (Giriraj),
Chang, Y.-P.C. (Yen-Pei C.),
F.J. Charchar (Fadi),
N. Chaturvedi (Nish),
Cho, Y.S. (Yoon Shin),
R. Clarke (Robert),
F.S. Collins (Francis),
Collins, R. (Rory),
J. Connell (John),
J.A. Cooper (Jackie A.),
M.N. Cooper (Matthew),
Cooper, R.S. (Richard S.),
A.M. Corsi (Anna Maria),
M. Dörr (Marcus),
S. Dahgam (Santosh),
J. Danesh (John),
A.V. Smith (Davey),
Day, I.N.M. (Ian N.M.),
P. Deloukas (Panagiotis),
M. Denniff (Matthew),
A. Dominiczak (Anna),
Y. Dong (Yanbin),
A. Doumatey (Ayo),
P. Elliott (Paul),
R. Elosua (Roberto),
J. Erdmann (Jeanette),
S. Eyheramendy (Susana),
M. Farrall (Martin),
C. Fava (Cristiano),
T. Forrester (Terrence),
Fowkes, F.G.R. (F. Gerald R.),
E.R. Fox (Ervin),
T.M. Frayling (Timothy),
Galan, P. (Pilar),
S.K. Ganesh (Santhi),
M. Garcia (Melissa),
T.R. Gaunt (Tom),
N.L. Glazer (Nicole),
Go, M.J. (Min Jin),
A. Goel (Anuj),
J. Gräßler (Jürgen),
D.E. Grobbee (Diederick),
L. Groop (Leif),
S. Guarrera (Simonetta),
X. Guo (Xiuqing),
Hadley, D. (David),
A. Hamsten (Anders),
Han, B.-G. (Bok-Ghee),
R. Hardy,
A.L. Hartikainen,
Heath, S. (Simon),
S.R. Heckbert (Susan),
B. Hedblad (Bo),
S. Hercberg (Serge),
D.G. Hernandez (Dena),
Hicks, A.A. (Andrew A.),
G. Hilton (Gina),
A. Hingorani (Aroon),
J.A. Hoffman Bolton (Judith),
J. Hopewell,
P. Howard (Philip),
S.E. Humphries (Steve),
S.C. Hunt (Steven),
K. Hveem (Kristian),
M.A. Ikram (Arfan),
M.A. Islam (M.),
Iwai, N. (Naoharu),
M.-R. Jarvelin (Marjo-Riitta),
A.U. Jackson (Anne),
T.H. Jafar (Tazeen),
C.S. Janipalli (Charles),
Johnson, T. (Toby),
S. Kathiresan (Sekar),
K.-T. Khaw (Kay-Tee),
Kim, H.-L. (Hyung-Lae),
S. Kinra (Sanjay),
Kita, Y. (Yoshikuni),
M. Kivimaki (Mika),
J.S. Kooner (Jaspal S.),
Kumar, M.J.K. (M.J. Kranthi),
Kuh, D. (Diana),
S.R. Kulkarni (Smita),
Kumari, M. (Meena),
J. Kuusisto (Johanna),
Kuznetsova, T. (Tatiana),
M. Laakso (Markku),
M. Laan (Maris),
J. Laitinen (Jaana),
Lakatta, E.G. (Edward G.),
C.D. Langefeld (Carl),
Larson, M.G. (Martin G.),
M. Lathrop (Mark),
D.A. Lawlor (Debbie),
R.W. Lawrence (Robert),
J.-Y. Lee (Jong-Young),
Lee, N.R. (Nanette R.),
D. Levy (Daniel),
Y. Li (Yulin),
W.T. Longstreth Jr,
Luan, J. (Jian'an),
G. Lucas (Gavin),
B. Ludwig (Barbara),
M. Mangino (Massimo),
Mani, K.R. (K. Radha),
Marmot, M.G. (Michael G.),
F.U.S. Mattace Raso (Francesco),
G. Matullo,
W.L. McArdle (Wendy),
C.A. McKenzie (Colin),
T. Meitinger (Thomas),
O. Melander (Olle),
P. Meneton (Pierre),
J.F. Meschia (James F.),
T. Miki (Tetsuro),
Milaneschi, Y. (Yuri),
Mohlke, K.L. (Karen L.),
V. Mooser (Vincent),
M.A. Morken (Mario),
,
T.H. Mosley (Thomas H.),
S.S. Najjar (Samer),
N. Narisu (Narisu),
C. Newton-Cheh (Christopher),
Nguyen, K.-D.H. (Khanh-Dung Hoang),
Nilsson, P. (Peter),
F. Nyberg (Fredrik),
C.J. O'Donnell (Christopher),
Ogihara, T. (Toshio),
Ohkubo, T. (Takayoshi),
Okamura, T. (Tomonori),
Ong, R.T.-H. (Rick Twee-Hee),
H. Ongen (Halit),
Onland-Moret, N.C. (N. Charlotte),
P.F. O'Reilly (Paul),
E. Org (Elin),
M. Orrù (Marco),
Palmas, W. (Walter),
J. Palmen (Jutta),
Palmer, L.J. (Lyle J.),
N.D. Palmer (Nicholette),
A.N. Parker (Alex),
J. Peden (John),
Peltonen, L. (Leena),
M. Perola (Markus),
V. Pihur (Vasyl),
C.P. Platou (Carl),
A.S. Plump (Andrew),
Prabhakaran, D. (Dorairajan),
B.M. Psaty (Bruce),
L.J. Raffel (Leslie),
Rao, D.C. (Dabeeru C.),
A. Rasheed (Asif),
F. Ricceri (Fulvio),
K.M. Rice (Kenneth),
A. Rosengren (Annika),
Rotter, J.I. (Jerome I.),
M.E. Rudock (Megan),
S. Sõber (Siim),
T. Salako (Tunde),
Saleheen, D. (Danish),
V. Salomaa (Veikko),
N.J. Samani (Nilesh),
S.M. Schwartz (Stephen),
P.E.H. Schwarz (Peter E. H.),
L.J. Scott (Laura),
Scott, J. (James),
A. Scuteri (Angelo),
J.S. Sehmi (Joban),
M. Seielstad (Mark),
,
P. Sharma (Pankaj),
S. Shaw-Hawkins (Sue),
Shi, G. (Gang),
N.R.G. Shrine (Nick),
E.J.G. Sijbrands (Eric),
X. Sim (Xueling),
A. Singleton,
M. Sjögren (Marketa),
N.L. Smith (Nicholas),
M.S. Artigas,
T.D. Spector (Timothy),
Staessen, J.A. (Jan A.),
A. Stancáková (Alena),
N.I. Steinle (Nanette),
D.P. Strachan (David P.),
H.M. Stringham (Heather),
Y.V. Sun (Yan),
A.J. Swift (Amy),
Y. Tabara (Yasuharu),
E.S. Tai (Shyong),
P.J. Talmud,
Taylor, A. (Andrew),
J. Terzic (Janos),
D.S. Thelle (Dag),
M.D. Tobin (Martin),
M. Tomaszewski (Maciej),
V. Tripathy (Vikal),
J. Tuomilehto (Jaakko),
I. Tzoulaki,
Uda, M. (Manuela),
H. Ueshima (Hirotsugu),
C.S.P.M. Uiterwaal (Cuno),
Umemura, S. (Satoshi),
P. van der Harst (Pim),
Y.T. van der Schouw (Yvonne),
W.H. van Gilst (Wiek),
E. Vartiainen (Erkki),
R.S. Vasan (Ramachandran Srini),
G. Veldre (Gudrun),
G.C. Verwoert (Germaine),
M. Viigimaa (Margus),
Vinay, D.G.,
P. Vineis (Paolo),
B.F. Voight (Benjamin),
P. Vollenweider (Peter),
L.E. Wagenknecht (Lynne),
Wain, L.V. (Louise V.),
X. Wang (Xiaoling),
T.J. Wang (Thomas),
N.J. Wareham (Nicholas J.),
H. Watkins (Hugh),
A.B. Weder (Alan),
P.H. Whincup (Peter),
K.L. Wiggins (Kerri),
J.C.M. Witteman (Jacqueline),
Wong, A. (Andrew),
Y. Wu (Ying),
C.S. Yajnik (Chittaranjan S.),
J. Yao (Jie),
J.C. Young (J. C.),
D. Zelenika (Diana),
G. Zhai (Guangju),
W. Zhang (Weihua),
F. Zhang (Feng),
J.H. Zhao (Jing Hua),
H. Zhu (Haidong),
X. Zhu (Xiaofeng),
Zitting, P. (Paavo),
E. Zukowska-Szczechowska (Ewa),
Y. Okada (Yukinori),
Wu, J.-Y. (Jer-Yuarn),
Gu, D. (Dongfeng),
Takeuchi, F. (Fumihiko),
Takahashi, A. (Atsushi),
Maeda, S. (Shiro),
Tsunoda, T. (Tatsuhiko),
Chen, P. (Peng),
Lim, S.-C. (Su-Chi),
Wong, T.-Y. (Tien-Yin),
J. Liu (Jianjun),
T.L. Young (Terri),
T. Aung (Tin),
Y.Y. Teo (Yik Ying),
Y.J. Kim (Young Jin),
Kang, D. (Daehee),
Chen, C.-H. (Chien-Hsiun),
Tsai, F.-J. (Fuu-Jen),
L.-C. Chang (Li-Ching),
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Hixson, J.E. (James E.),
S. Chen (Shufeng),
T. Katsuya (Tomohiro),
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E. Albrecht (Eva),
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N. Kato (Norihiro),
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T. Tanaka (Toshihiro),
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H. Schunkert (Heribert),
T.L. Assimes (Themistocles),
A.S. Hall (Alistair),
C. Hengstenberg (Christian),
I.R. König (Inke),
R. Laaksonen (Reijo),
R. McPherson (Ruth),
J.R. Thompson (John),
U. Thorsteinsdottir (Unnur),
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D. Absher (Devin),
L. Chen (Li),
L.A. Cupples (Adrienne),
E. Halperin (Eran),
M. Li (Mingyao),
K. Musunuru (Kiran),
M. Preuss (Michael),
A. Schillert (Arne),
G. Thorleifsson (Gudmar),
G.A. Wells (George),
H. Holm (Hilma),
R. Roberts (Robert),
A.F. Stewart (Alexandre F.),
S.P. Fortmann (Stephen),
A.T.J.I. Go (Attie),
M.A. Hlatky (Mark),
C. Iribarren (Carlos),
J.W. Knowles (Joshua),
R.H. Myers (Richard),
T. Quertermous (Thomas),
Sidney, S. (Steven),
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Tang, H. (Hua),
S. Blankenberg (Stefan),
R.B. Schnabel (Renate),
C. Sinning (Christoph),
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L. Tiret (Laurence),
V. Nicaud,
F. Cambien (François),
H. Bickel (Horst),
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C. Proust (Carole),
T. Munzel (Thomas),
M. Barbalic (maja),
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S. Demissie-Banjaw (Serkalem),
A.R. Folsom (Aaron),
T. Lumley (Thomas),
K. Marciante (Kristin),
K.D. Taylor (Kent D.),
K.A. Volcik (Kelly),
S. Gretarsdottir (Solveig),
J.R. Gulcher (Jeffrey),
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J-A. Zwart (John-Anker),
G. Thorgeirsson (Gudmundur),
K.K. Andersen (Karl),
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A. Großhennig (Anika),
P. Linsel-Nitschke (Patrick),
K. Stark (Klaus),
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Z. Aherrahrou (Zouhair),
P. Bruse (Petra),
A. Doering (Angela),
N. Klopp (Norman),
P. Diemert (Patrick),
C. Loley (Christina),
A. Medack (Anja),
J. Nahrstedt (Janja),
A. Peters (Annette),
A.K. Wagner (Arnika),
C. Willenborg (Christina),
Böhm, B.O. (Bernhard O.),
H. Dobnig (Harald),
T.B. Grammer (Tanja),
Hoffmann, M.M. (Michael M.),
A. Meinitzer (Andreas),
B. Winkelmann,
S. Pilz (Stefan),
W. Renner (Wilfried),
H. Scharnagl (Hubert),
T. Stojakovic (Tatjana),
A. Tomaschitz (Andreas),
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C. Guiducci (Candace),
N.P. Burtt (Noël),
S.B. Gabriel (Stacey),
S. Dandona (Sonny),
O. Jarinova (Olga),
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A. Wilensky (Asaf),
W. Matthai (William),
H. Hakonarson (Hakon),
J. Devaney (Joseph),
M.S. Burnett,
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Kent, K.M. (Kenneth M.),
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Lindsay, J.M. (Joseph M.),
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C.W. Knouff (Christopher),
D.M. Waterworth (Dawn),
M.C. Walker (Max),
S.E. Epstein (Stephen E.),
D.J. Rader (Daniel),
C.P. Nelson (Christopher P.),
B.J. Wright (Benjamin),
A.J. Balmforth (Anthony),
Ball, S.G. (Stephen G.),
L.R. Loehr (Laura),
W.D. Rosamond (Wayne),
E.J. Benjamin (Emelia),
T. Haritunians (Talin),
D.J. Couper (David),
J. Murabito (Joanne),
Wang, Y.A. (Ying A.),
B.H.Ch. Stricker (Bruno),
Chang, P.P. (Patricia P.),
Willerson, J.T. (James T.),
S.B. Felix (Stephan),
N. Watzinger (Norbert),
J. Aragam (Jayashri),
R. Zweiker (Robert),
L. Lind (Lars),
R.J. Rodeheffer (Richard),
K.H. Greiser (Karin Halina),
J.W. Deckers (Jaap),
J. Stritzke (Jan),
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I. Kullo (Iftikhar),
J. Haerting (Johannes),
T. Reffelmann (Thorsten),
M.M. Redfield (Margaret),
K. Werdan (Karl),
G.F. Mitchell (Gary),
D.K. Arnett (Donna),
J.S. Gottdiener (John),
M. Blettner (Maria),
N. Friedrich (Nele),
P. Kovacs (Peter),
P.S. Wild (Philipp S.),
P. Froguel (Philippe),
R. Rettig (Rainer),
R. Mägi (Reedik),
R. Biffar (Reiner),
R. Schmidt (Reinhold),
R.P.S. Middelberg (Rita),
Carroll, R.J. (Robert J.),
B.W.J.H. Penninx (Brenda),
R. Scott (Rodney),
Katz, R. (Ronit),
S. Sedaghat (Sanaz),
S. Wild (Sarah),
S.L.R. Kardia (Sharon),
S. Ulivi (Shelia),
Hwang, S.-J. (Shih-Jen),
S. Enroth (Stefan),
S. Kloiber (Stefan),
S. Trompet (Stella),
B. Stengel (Bernd),
Hancock, S.J. (Stephen J.),
S.T. Turner (Stephen),
S.E. Rosas (Sylvia E.),
S. Stracke (Sylvia),
T.B. Harris (Tamara),
T. Zeller (Tanja),
T. Zemunik (Tatijana),
T. Lehtimäki (Terho),
T. Illig (Thomas),
T. Aspelund (Thor),
T. Nikopensius (Tiit),
T. Esko (Tõnu),
,
U. Gyllensten (Ulf),
U. Völker (Uwe),
V. Emilsson (Valur),
Vitart, V. (Veronique),
V. Aalto (Ville),
V. Gudnason (Vilmundur),
V. Chouraki (Vincent),
Chen, W.-M. (Wei-Min),
W. Igl (Wilmar),
W. März (Winfried),
W. Koenig (Wolfgang),
W. Lieb (Wolfgang),
R.J.F. Loos (Ruth),
Y. Liu (YongMei),
H. Snieder (Harold),
P.P. Pramstaller (Peter Paul),
A. Parsa (Afshin),
O'Connell, J.R. (Jeffrey R.),
Susztak, K. (Katalin),
P. Hamet (Pavel),
J. Tremblay (Johanne),
I.H. de Boer (Ian),
C.A. Böger (Carsten),
W. Goessling (Wolfram),
D.I. Chasman (Daniel),
A. Köttgen (Anna),
W.H.L. Kao (Wen)
and
C.S. Fox (Caroline)
2016-01-21
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Publication
Publication
Nature Communications , Volume 7
Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
| Additional Metadata | |
|---|---|
| Persistent URL | doi.org/10.1038/ncomms10023, hdl.handle.net/1765/96894 |
| Journal | Nature Communications |
| Organisation | Department of Epidemiology |
| Citation |
Pattaro, C., Teumer, A., Gorski, M., Chu, A., Li, M., Mijatovic, V. (Vladan), … Fox, C. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7. doi:10.1038/ncomms10023 |