2016-09-01
Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations
Publication
Publication
Cancer Research , Volume 76 - Issue 17 p. 5103- 5114
Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2BAS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancerassociated loci, identifying common mechanisms of cancer development and progression.
| Additional Metadata | |
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| doi.org/10.1158/0008-5472.CAN-15-2980, hdl.handle.net/1765/97022 | |
| Cancer Research | |
| Organisation | Department of Epidemiology |
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Fehringer, G. (Gordon), Kraft, P., Pharoah, P., Eeles, R., Chatterjee, N. (Nilanjan), Schumacher, F. R., … Hung, R. (2016). Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations. Cancer Research, 76(17), 5103–5114. doi:10.1158/0008-5472.CAN-15-2980 |
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