2016-02-01
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Publication
Publication
Nature Communications , Volume 7
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (Po5108), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
| Additional Metadata | |
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| doi.org/10.1038/ncomms10495, hdl.handle.net/1765/97064 | |
| Nature Communications | |
| Organisation | Department of Internal Medicine |
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Lu, Y., & Loos, R. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7. doi:10.1038/ncomms10495 |
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