Within the wide off-label use of drugs in children, there is a need for proven effectiveness of drugs in children. Although new drugs need to be studied in children as per European and US regulations, new evidence is only very slowly generated because of ethical, financial, and practical barriers to conduct trials in children.
Janiaud et al. now challenge the current paradigm that drugs always need to be studied in children and question if data cannot be extrapolated from adults. [...]