2016-07-01
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
Publication
Publication
Nature Communications , Volume 7
Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10-8), 6q21 (rs9372120, P=9.09 × 10-15), 7q36.1 (rs7781265, P=9.71 × 10-9), 8q24.21 (rs1948915, P=4.20 × 10-11), 9p21.3 (rs2811710, P=1.72 × 10-13), 10p12.1 (rs2790457, P=1.77 × 10-8), 16q23.1 (rs7193541, P=5.00 × 10-12) and 20q13.13 (rs6066835, P=1.36 × 10-13), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
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| doi.org/10.1038/ncomms12050, hdl.handle.net/1765/97239 | |
| Nature Communications | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Mitchell, J.S. (Jonathan S.), Li, N. (Ni), Weinhold, N. (Niels), Försti, A., Ali, M. (Mina), van Duin, M., … Houlston, R. (2016). Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. Nature Communications, 7. doi:10.1038/ncomms12050 |
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