2016-07-15
Exploiting DNA repair defects for novel cancer therapies
Publication
Publication
Molecular Biology of the Cell (Print) , Volume 27 - Issue 14 p. 2145- 2148
Most human tumors accumulate a multitude of genetic changes due to defects in the DNA damage response. Recently, small-molecule inhibitors have been developed that target cells with specific DNA repair defects, providing hope for precision treatment of such tumors. Here we discuss the rationale behind these therapies and how an important bottleneck-patient selection-can be approached.
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| doi.org/10.1091/mbc.E15-10-0698, hdl.handle.net/1765/97634 | |
| Molecular Biology of the Cell (Print) | |
| Organisation | Department of Radiation Oncology |
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van Gent, D., & Kanaar, R. (2016). Exploiting DNA repair defects for novel cancer therapies. Molecular Biology of the Cell (Print) (Vol. 27, pp. 2145–2148). doi:10.1091/mbc.E15-10-0698 |
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