2017-02-01
Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second
Publication
Publication
Biomedical Optics Express , Volume 8 - Issue 2 p. 943- 953
Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s−1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.
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| doi.org/10.1364/BOE.8.000943, hdl.handle.net/1765/97721 | |
| Biomedical Optics Express | |
| Organisation | Department of Biomedical Engineering |
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Wu, M., Springeling, T., Lovrak, M., Mastik, F., Iskander-Rizk, S., Wang, T., … van Soest, G. (2017). Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second. Biomedical Optics Express, 8(2), 943–953. doi:10.1364/BOE.8.000943 |
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