Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second
Lipid deposition can be assessed with combined intravascular photoacoustic/ultrasound (IVPA/US) imaging. To date, the clinical translation of IVPA/US imaging has been stalled by a low imaging speed and catheter complexity. In this paper, we demonstrate imaging of lipid targets in swine coronary arteries in vivo, at a clinically useful frame rate of 20 s−1. We confirmed image contrast for atherosclerotic plaque in human samples ex vivo. The system is on a mobile platform and provides real-time data visualization during acquisition. We achieved an IVPA signal-to-noise ratio of 20 dB. These data show that clinical translation of IVPA is possible in principle.
|Keywords||Imaging systems, Photoacoustic imaging|
|Persistent URL||dx.doi.org/10.1364/BOE.8.000943, hdl.handle.net/1765/97721|
|Journal||Biomedical Optics Express|
Wu, M, Springeling, T, Lovrak, M, Mastik, F, Iskander-Rizk, S, Wang, T, … van Soest, G. (2017). Real-time volumetric lipid imaging in vivo by intravascular photoacoustics at 20 frames per second. Biomedical Optics Express, 8(2), 943–953. doi:10.1364/BOE.8.000943