BACKGROUND: We have previously reported a virtual absence of neointimal hyperplasia 4 months after implantation of sirolimus-eluting stents. The aim of the present investigation was to determine whether these results are sustained over a period of 1 year. METHODS AND RESULTS: Forty-five patients with de novo coronary disease were successfully treated with the implantation of a single sirolimus-eluting Bx VELOCITY stent in Sao Paulo, Brazil (n=30, 15 fast release [group I, GI] and 15 slow release [GII]) and Rotterdam, The Netherlands (15 slow release, GIII). Angiographic and volumetric intravascular ultrasound (IVUS) follow-up was obtained at 4 and 12 months (GI and GII) and 6 months (GIII). In-stent minimal lumen diameter and percent diameter stenosis remained essentially unchanged in all groups (at 12 months, GI and GII; at 6 months, GIII). Follow-up in-lesion minimal lumen diameter was 2.28 mm (GIII), 2.32 mm (GI), and 2.48 mm (GII). No patient approached the >/=50% diameter stenosis at 1 year by angiography or IVUS assessment, and no edge restenosis was observed. Neointimal hyperplasia, as detected by IVUS, was virtually absent at 6 months (2+/-5% obstruction volume, GIII) and at 12 months (GI=2+/-5% and GII=2+/-3%). CONCLUSIONS: This study demonstrates a sustained suppression of neointimal proliferation by sirolimus-eluting Bx VELOCITY stents 1 year after implantation.

*Stents/adverse effects, Blood Vessel Prosthesis Implantation/adverse effects/*instrumentation/methods, Brazil, Cohort Studies, Coronary Angiography, Coronary Disease/diagnosis/drug therapy/*surgery, Delayed-Action Preparations/administration & dosage, Drug Implants/administration & dosage, Endosonography, Female, Follow-Up Studies, Graft Occlusion, Vascular/etiology/*prevention & control, Humans, Male, Middle aged, Netherlands, Sirolimus/*administration & dosage/adverse effects, Survival Rate, Treatment Outcome, Tunica Intima/drug effects, Vascular Patency/drug effects
Circulation (Baltimore)
Erasmus MC: University Medical Center Rotterdam

Sousa, J.E, van Langenhove, G.J.J, Sousa, A.G.M.R, Falotico, R, Popma, J.J, Jaeger, J, … Serruys, P.W.J.C. (2001). Sustained suppression of neointimal proliferation by sirolimus-eluting stents: one-year angiographic and intravascular ultrasound follow-up. Circulation (Baltimore), 104(17), 2007–2011. Retrieved from