2017-02-07
Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial
Publication
Publication
BMC Cancer , Volume 17 - Issue 1
The "TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia" (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clinical applicability of imiquimod 5% cream in high-grade cervical intraepithelial neoplasia (CIN). The lagging inclusions were mainly due to a strong patient preference for either of the two treatment modalities. This prompted us to initiate a new study on the same subject, with a non-randomized, open-label design: the 'TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC)-3' study. Original TOPIC-trial: Medical Ethics Committee approval number METC13231; ClinicalTrials.gov Identifier: NCT02329171, 22 December 2014. TOPIC-3 study: Medical Ethics Committee approval number METC162025; ClinicalTrials.gov Identifier: NCT02917746, 16 September 2016..
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| doi.org/10.1186/s12885-017-3108-9, hdl.handle.net/1765/97893 | |
| BMC Cancer | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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Koeneman, M., Kruse, A. J., Kooreman, L. F. S., Zur Hausen, A., Hopman, A., Sep, S., … Kruitwagen, R. (2017). Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial. BMC Cancer, 17(1). doi:10.1186/s12885-017-3108-9 |
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