Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

*RNA-Binding Proteins, Amino Acid Sequence, Antigenic Variation, Epitopes/*immunology, HLA-B35 Antigen/*metabolism, Humans, Influenza A virus/genetics/*immunology, Molecular Sequence Data, Nucleoproteins/*genetics/*immunology, Research Support, Non-U.S. Gov't, T-Lymphocytes, Cytotoxic/*immunology, Viral Core Proteins/*genetics/*immunology
Journal of Virology
Erasmus MC: University Medical Center Rotterdam

Boon, A.C.M, de Mutsert, G, Graus, Y.M.F, Fouchier, R.A.M, Sintnicolaas, K, Rimmelzwaan, G.F, & Osterhaus, A.D.M.E. (2002). Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes. Journal of Virology. Retrieved from