Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

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Journal of Virology
Erasmus MC: University Medical Center Rotterdam

Boon, A., de Mutsert, G., Graus, Y. M. F., Fouchier, R., Sintnicolaas, K., Rimmelzwaan, G., & Osterhaus, A. (2002). Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes. Journal of Virology. Retrieved from