Effect of physical activity and/or healthy eating ongdm risk: The dali lifestyle study
Lifestyle approaches for preventing gestational diabetes mellitus (GDM) have produced mixed results.
The aim of the present study was to compare the effectiveness of 3 lifestyle interventions [healthy eating (HE), physical activity (PA), and both HE and PA (HE+PA)] with usual care (UC) in reducing GDM risk.
The present study was a multicenter randomized controlled trial conducted from 2012 to 2014 [the DALI (vitamin D and lifestyle intervention for GDM prevention) lifestyle study].
The study occurred at antenatal clinics across 11 centers in 9 European countries.
Consecutive pregnant women at <20 weeks of gestation with a body mass index (BMI) of ≥29 kg/m2 and without GDM using the International Association of Diabetes and Pregnancy Study Group criteria (n = 436). For the intervention, women were randomized, stratified by site, to UC, HE, PA, or HE+PA. The women received 5 face-to-face and ≤4 telephone coaching sessions using the principles of motivational interviewing. A gestational weight gain (GWG) <5 kg was targeted. The coaches received standardized training and an intervention toolkit tailored to their culture and language.
Main Outcome Measures:
The endpoints were the GWG at 35 to 37 weeks and the fasting glucose and insulin sensitivity [homeostasis model assessment insulin resistance (HOMA-IR)] at 24 to 28 weeks.
We randomized 108 women to HE+PA, 113 to HE, 110 to PA, and 105 to UC. In the HE+PA group, but not HE or PA alone, women achieved substantially less GWG than did the controls (UC) by 35 to 37 weeks (−2.02; 95% confidence interval, −3.58 to −0.46 kg). Despite this reduction, no improvements were seen in fasting or postload glucose levels, insulin concentrations, or HOMA-IR. The birthweights and large and small for gestational age rates were similar.
The combined HE+PA intervention was able to limit GWG but did not reduce fasting glycemia. Thus, lifestyle changes alone are unlikely to prevent GDM among women with a BMI of ≥29 kg/m2.
|Keywords||physical activity pregnancy body mass index procedure glucose gestational diabetes fasting infant, small for gestational age life style fasting blood glucose measurement insulin weight gain in pregnancy healthy diet prevention|
|Persistent URL||dx.doi.org/10.1210/jc.2016-3455, hdl.handle.net/1765/98636|
|Journal||Journal of Clinical Endocrinology and Metabolism|
Simmons, D, Devlieger, R, Van Assche, A, Jans, G, Galjaard, S, Corcoy, R, … van Poppel, M.N. (2017). Effect of physical activity and/or healthy eating ongdm risk: The dali lifestyle study. Journal of Clinical Endocrinology and Metabolism, 102(3), 903–913. doi:10.1210/jc.2016-3455