Inhibition of complement in Guillain-Barré syndrome: the ICA-GBS study
The outcome of Guillain-Barré syndrome (GBS) remains unchanged since plasma exchange and intravenous immunoglobulin (IVIg) were introduced over 20 years ago. Pathogenesis studies on GBS have identified the terminal component of complement cascade as a key disease mediator and therapeutic target. We report the first use of terminal complement pathway inhibition with eculizumab in humans with GBS. In a randomised, double-blind, placebo-controlled trial, 28 subjects eligible on the basis of GBS disability grade of at least 3 were screened, of whom 8 (29%) were randomised. Five received eculizumab for 4 weeks, alongside standard IVIg treatment. The safety outcomes, monitored via adverse events capture, showed eculizumab to be well-tolerated and safe when administered in conjunction with IVIg. Primary and secondary efficacy outcomes in the form of GBS disability scores (GBS DS), MRC sum scores, Rasch overall disability scores, and overall neuropathy limitation scores are reported descriptively. For the primary efficacy outcome at 4 weeks after recruitment, two of two placebo- and two of five eculizumab-treated subjects had improved by one or more grades on the GBS DS. Although the small sample size precludes a statistically meaningful analysis, these pilot data indicate further studies on complement inhibition in GBS are warranted.
|Keywords||clinical trial, complement, eculizumab, Guillain-Barré syndrome, intravenous immunoglobulin, membrane attack complex, therapy|
|Persistent URL||dx.doi.org/10.1111/jns.12194, hdl.handle.net/1765/98643|
|Journal||Journal of the Peripheral Nervous System|
Davidson, A.I. (Amy I.), Halstead, S.K, Goodfellow, J.A. (John A.), Chavada, G. (Govind), Mallik, A. (Arup), Overell, J. (James), … Willison, H.J. (2017). Inhibition of complement in Guillain-Barré syndrome: the ICA-GBS study. Journal of the Peripheral Nervous System, 22(1), 4–12. doi:10.1111/jns.12194