Role of Genetic Haploinsufficiency in the Biology and Targeted Therapy of Del(5q) Myelodysplastic Syndrome

In the current study it was our goal to focus on important design criteria including
(1) the opportunity for reproducible and user-defined properties such as the choice of substrate, extracellular matrix, cell types, and degradability;
(2) the ability to induce vascularisation;
(3) accessibility and suitability for complementary histological/cytological analysis; and, most importantly,
(4) the functional ability to capture and retrieve endogenous hematopoietic cells efficiently.