Imaging stent-thrombus interaction in mechanical thrombectomy
A 52-year-old man had a right M1 occlusion, treated with mechanical intra-arterial therapy. After 5 minutes of intra-arterial embedding, the stentriever containing thrombus was retrieved, rinsed, and fixed for microscopy. MicroCT scanning electron and light microscopy was performed on the stentriever to assess stent–thrombus interaction (figure). Twenty-three sites of interaction between thrombus and stentriever were analyzed. Interaction was not mechanical at 12 of these sites. We observed fibrin cross-bridges connecting thrombus to stent wires. Fibrin also created smooth covers overlying erythrocyte-rich areas. Light microscopy further showed thrombus interspersed with leukocytes, consisting of fibrin- and platelet-rich areas coalescing around the stent wire.
|Persistent URL||dx.doi.org/10.1212/WNL.0000000000003487, hdl.handle.net/1765/98802|
van Es, A.C.G.M, Autar, A, Emmer, B.J, Lycklama à Nijeholt, G.J, van der Kallen, B.F.W, & van Beusekom, H.M.M. (2017). Imaging stent-thrombus interaction in mechanical thrombectomy. Neurology, 88(2), 216–217. doi:10.1212/WNL.0000000000003487