Raman Spectroscopy to Distinguish Tongue Cancer From Healthy Tissue
Het gebruik van Raman spectrosopie om tongkanker van gezond weefsel te onderscheiden
The main goal of this thesis is to provide a solid foundation for further development of Raman spectroscopic applications in head and neck oncology. This is a multistep process in which we want to investigate and understand the Raman spectroscopic features that distinguish the epithelial (keratinocytic) component of a tongue OCSCC from its surrounding tissue (referred to as non-tumorous or healthy tissue).
First, we aimed to develop a standardized method to collect and analyze detailed Raman spectral information
of OCSCC and the individual non-tumorous tissue structures in the tongue, as described in Chapter 2. Next,
the potential of Raman spectroscopy to distinguish between the characteristic Raman features of OCSCC
and the individual non-tumorous tissue structures is investigated in Chapter 3. In Chapter 4, these results
are used for the development of a ‘tumor’ versus ‘non-tumorous tissue’ classification model. Lastly, in
Chapter 5 the Raman spectra of OCSCC and individual non-tumorous tissue structures are analyzed in
terms of the quantitative information they contain about the tissue’s molecular composition. In Chapter 6
an overview is given of the pure-compound reference spectra used for this analysis.
To conclude, in this thesis the strengths and limitations of Raman spectroscopy, regarding its OCSCCdetecting potential in tongue, are elucidated.
|Promotor||R.J. Baatenburg de Jong (Robert Jan) , S. Koljenović (Senada) , G.J. Puppels (Gerwin)|
|Publisher||Erasmus University Rotterdam|
Cals, F.L.J. (2017, May 3). Raman Spectroscopy to Distinguish Tongue Cancer From Healthy Tissue. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/98903