Human papillomavirus (HPV) is a highly prevalent sexually transmitted virus, of which 150 types have been completely sequenced. Currently, about 14 HPV-types are considered ‘high risk’ for their potential to cause cervical cancer, the fourth most common cancer among women worldwide. In particular HPV-16 and HPV-18 are predominantly present in precancerous lesions and invasive cervical cancer. Luckily, vaccines have been developed to protect against these HPV-types. This thesis includes modeling studies in which we explore the role of naturally acquired immunity after clearing an HPV-16 and HPV-18 infection in the spread of HPV, as well as the impact of HPV vaccination on HPV and cervical cancer in the Netherlands.

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H.J. de Koning (Harry) , S.J. de Vlas (Sake)
Erasmus University Rotterdam
hdl.handle.net/1765/98975
Netherlands Institute for Health Science (NIHES)

Matthijsse, S. (2017, May 3). The impact of HPV vaccination on HPV and cervical cancer in the Netherlands. Retrieved from http://hdl.handle.net/1765/98975