Postoperative administration of metamizole for one single day

We read the study by Fieler et al. with great interest. Their study addresses an important aspect of postoperative analgesia management. They did not report any cases of agranulocytosis following metamizole administration in more than 1000 children. A single dose of intravenous metamizole for treatment of postoperative pain seems to be well tolerated without adverse events directly related to metamizole administration. We would like to report a retrospective cohort investigation we performed in 2012, on consecutive adult patients, with the aim of investigating whether postoperative intravenous metamizole leads to agranulocytosis.

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