This study examined whether the association between age and amygdala-medial prefrontal cortex (mPFC) connectivity in typically developing 6- to 10-year-old children is correlated with parental care. Resting-state functional magnetic resonance imaging scans were acquired from 124 children of the Generation R Study who at 4 years old had been observed interacting with their parents to assess maternal and paternal sensitivity. Amygdala functional connectivity was assessed using a general linear model with the amygdalae time series as explanatory variables. Higher level analyses assessing Sensitivity × Age as well as exploratory Sensitivity × Age × Gender interaction effects were performed restricted to voxels in the mPFC. We found significant Sensitivity × Age interaction effects on amygdala-mPFC connectivity. Age was related to stronger amygdala-mPFC connectivity in children with a lower combined parental sensitivity score (b = 0.11, p =.004, b = 0.06, p =.06, right and left amygdala, respectively), but not in children with a higher parental sensitivity score, (b = -0.07, p =.12, b = -0.06, p =.12, right and left amygdala, respectively). A similar effect was found for maternal sensitivity, with stronger amygdala-mPFC connectivity in children with less sensitive mothers. Exploratory (parental, maternal, paternal) Sensitivity × Age × Gender interaction analyses suggested that this effect was especially pronounced in girls. Amygdala-mPFC resting-state functional connectivity has been shown to increase from age 10.5 years onward, implying that the positive association between age and amygdala-mPFC connectivity in 6- to 10-year-old children of less sensitive parents represents accelerated development of the amygdala-mPFC circuit.

Additional Metadata
Persistent URL dx.doi.org/10.1017/S0954579417000141, hdl.handle.net/1765/99256
Journal Development and Psychopathology
Citation
Thijssen, S, Muetzel, R.L, Bakermans-Kranenburg, M.J, Jaddoe, V.W.V, Tiemeier, H.W, Verhulst, F.C, … van IJzendoorn, M.H. (2017). Insensitive parenting may accelerate the development of the amygdala-medial prefrontal cortex circuit. Development and Psychopathology, 29(2), 505–518. doi:10.1017/S0954579417000141