AIMS: Intracoronary radiation is a promising therapy potentially reducing restenosis following catheter-based interventions. Currently, only limited data on this treatment are available. The feasibility and outcome in daily routine practice, however, is unknown. METHODS AND RESULTS: In 100 consecutive patients, intracoronary beta-radiation was performed with a (90)Strontium system (Novoste Beta-Cathtrade mark) following angioplasty. Predominantly complex (73% type B2 and C) and long lesions (length 24.3+/-15.3 mm) were included (37% de novo, 19% restenotic and 44% in-stent restenotic lesions). Radiation success was 100%. Mean prescribed dose was 19.8+/-2.5 Gy. A pullback procedure was performed in 19% lesions. Geographic miss occurred in 8% lesions. Periprocedural thrombus formation occurred in four lesions, dissection in nine lesions. During hospital stay, no death, acute myocardial infarction, or repeat revascularization was observed. Major adverse cardiac events occurred predominantly between 6 and 12 months after the index procedure with major adverse cardiac event-free survival of 66% at 12 months (one death, 10 Q-wave myocardial infarctions, 23 target vessel revascularizations; ranked for worst event). CONCLUSION: Routine catheter-based intracoronary beta-radiation therapy after angioplasty is safe and feasible with a high acute procedural success. The clinical 1-year follow-up showed delayed occurrence of major adverse cardiac events between 6 and 12 months after the index procedure

Aged, Angioplasty, Transluminal, Percutaneous Coronary, Beta Rays/therapeutic use, Brachytherapy/*methods, Coronary Restenosis/*radiotherapy, Disease-Free Survival, Female, Follow-Up Studies, Humans, Male, Middle aged, Prospective Studies, Research Support, Non-U.S. Gov't, Strontium Radioisotopes/therapeutic use, radioisotopes, safety
dx.doi.org/10.1053/euhj.2001.3045, hdl.handle.net/1765/9929
European Heart Journal
Erasmus MC: University Medical Center Rotterdam

Rensing, B.J.W.M, Smits, P.C, Vos, J, Wardeh, A.J, Knook, A.H.M, Kozuma, K, … Sianos, G. (2002). Routine intracoronary beta-irradiation. Acute and one year outcome in patients at high risk for recurrence of stenosis. European Heart Journal, 23(13), 1038–1044. doi:10.1053/euhj.2001.3045