2017-05-24
Optimizing TB treatment
Publication
Publication
Optimaliseren van de behandeling van tuberculose
The overall aim of this thesis is to explore and study new therapeutic options to optimize TB treatment.
The specific objectives are:
– To assess the therapeutic potential of co-administration of efflux pump inhibitors, i.e. thioridazine or SILA-421 with the standard treatment regimen
– To study a moxifloxacin and linezolid combination as a novel treatment regimen for MDR-TB and potentiate this combination with efflux pump inhibitors and cell wall destabilizing drugs
– To characterize the effect of rifampicin on the transcription profile of a rifampicin-susceptible and a rifampicin-resistant Mycobacterium tuberculosis strain
– To study the added value of using a Mycobacterium tuberculosis strain of the clinical highly relevant Beijing genotype in our mouse TB model
– To compare Colony Forming Units counting, the Time to Positivity assay and the Molecular Bacterial Load assay, and explore whether the last assays can detect a mycobacterial subpopulation which is unable to grown on solid media
| Additional Metadata | |
|---|---|
| , , , , | |
| H.P. Endtz (Hubert) , Mouton, J.W., J.E.M. de Steenwinkel (Jurriaan) | |
| Erasmus University Rotterdam | |
| hdl.handle.net/1765/99316 | |
| Organisation | Department of Medical Microbiology and Infectious Diseases |
|
de Knegt, G. (2017, May 24). Optimizing TB treatment. Retrieved from http://hdl.handle.net/1765/99316 |
|
