Genaesthics : Breast Surgery in BRCA1/2 Gene Mutation Carriers

The present thesis focuses on breast surgery in BRCA1/2 gene mutation carriers. The topics that are studied vary broadly, representing the multiple disciplines that are involved in the diagnostic work-up and treatment of BRCA1/2-associated breast cancer.
The first part contains studies on molecular and prognostic tumor characteristics in breast cancer. The thesis continues with an anatomical study on safety of prophylactic mastectomy, and finishes with studies on aesthetics and patient reported outcomes of prophylactic breast surgery and breast reconstruction.
The title ‘Genaesthics’ is a merger of the two extremities of this spectrum: ‘genetics’ and ‘aesthetics’.