Tissue Distribution of the MERS-Coronavirus Receptor in Bats
Middle East respiratory syndrome coronavirus (MERS-CoV) has been shown to infect both humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor.The distribution of DPP4 in the respiratory tract tissues of humans and camels reflects MERS-CoV tropism.Apart from dromedary camels, insectivorous bats are suggested as another natural reservoir for MERS-like-CoVs.In order to gain insight on the tropism of these viruses in bats, we studied the DPP4 distribution in the respiratory and extra-respiratory tissues of two frugivorous bat species (Epomophorus gambianus and Rousettus aegyptiacus) and two insectivorous bat species (Pipistrellus pipistrellus and Eptesicus serotinus).In the frugivorous bats, DPP4 was present in epithelial cells of both the respiratory and the intestinal tract, similar to what has been reported for camels and humans.In the insectivorous bats, however, DPP4 expression in epithelial cells of the respiratory tract was almost absent.The preferential expression of DPP4 in the intestinal tract of insectivorous bats, suggests that transmission of MERS-like-CoVs mainly occurs via the fecal-oral route.Our results highlight differences in the distribution of DPP4 expression among MERS-CoV susceptible species, which might influence variability in virus tropism, pathogenesis and transmission route.
|Persistent URL||dx.doi.org/10.1038/s41598-017-01290-6, hdl.handle.net/1765/99895|
Widagdo, W, Begeman, L, Schipper, D, van Run, P.R.W.A, Cunningham, A.A. (Andrew A), Kley, N. (Nils), … van den Brand, J.M.A. (2017). Tissue Distribution of the MERS-Coronavirus Receptor in Bats. Scientific Reports, 7(1). doi:10.1038/s41598-017-01290-6